|
KMID : 1137020190300040053
|
|
Journal of Gynecologic Oncology
2019 Volume.30 No. 4 p.53 ~ p.53
|
|
|
Impact of vaginal brachytherapy in intermediate and high-intermediate risk endometrial cancer: a multicenter study from the FRANCOGYN group
|
|
Reboux Pierre-Alain
Azais Henri
Canova Charles-Henry
Bendifallah Sofiane
Ouldamer Lobna
Raimond Emilie
Hudry Delphine
Coutant Charles
Graesslin Olivier
Touboul Cyril
Collinet Pierre
Bricou Alexandre
Huchon Cyrille
Darai Emile
Ballester Marcos
Leveque Jean
Lavoue Vincent
Koskas Martin
Uzan Catherine
Canlorbe Geoffroy
|
|
|
Abstract
|
|
|
Objective: According to recent European Society of Medical Oncology, European Society of Gynaecological Oncology and European Society of Radiotherapy and Oncology guidelines, adjuvant vaginal brachytherapy (VB) is optional in patients with intermediate risk (IR) and high-intermediate risk (HIR) endometrial cancer (EC). The aim of this French retrospective, multicenter study was to assess the impact of VB in these groups on local recurrence rate, local recurrence-free survival (RFS) and overall survival (OS).
Methods: Data of 191 patients with IR and HIR EC who underwent primary surgery with or without VB and no other adjuvant treatment between 2000 and 2016 were extracted from the FRANCOGYN database. Rate of local recurrence, OS and local RFS in these two groups were compared using the Kaplan-Meier method.
Results: The number of patients with IR and HIR EC were 118 and 73 respectively. VB was used in 92 patients in IR group and 43 in HIR group. Median follow-up was 22 months. In the HIR group, the local recurrence rate was significantly higher in the no adjuvant therapy group in comparison with the VB group (16.7% and 0% respectively, p=0.02). There was also a significant improvement in local RFS (p=0.01) in VB group. In IR EC, there is no significant difference on local recurrence rate (4.2% and 3.2%, respectively, p=1.00) or local RFS (p=0.54) between the two groups.
Conclusions: VB is an efficient adjuvant treatment for patients with HIR EC. VB is not associated with an improvement of RFS or OS in IR EC patient.
|
|
|
KEYWORD
|
|
|
Endometrial Cancer, Brachytherapy, Local Neoplasm Recurrence
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
    
|